Chromosomal instability associated with duplications in maize
نویسندگان
چکیده
منابع مشابه
Oncogenic transformation by SEI-1 is associated with chromosomal instability.
Amplification of SEI-1, a cell cycle regulatory gene at 19q13.1, is commonly detected in ovarian cancer, suggesting a role in the pathogenesis of ovarian cancer. In the present study, the oncogenic potential of SEI-1 was shown by anchorage-independent growth and tumor formation in nude mice with SEI-1-transfected NIH 3T3 mouse fibroblast cells. Silencing of SEI-1 gene expression by small interf...
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Chromosomal interchanges, or reciprocal translocations, in maize are of primary interest because of the opportunities they offer for the study of chromosome behavior and crossing over. The great volume of work which has been done on crossing over and on translocations in Drosophila has yielded an abundance of statistical data on crossing over and chromosome distribution. For this type of work D...
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BACKGROUND Patients suffering from ulcerative colitis (UC) bear an increased risk for colorectal cancer. Due to the sparsity of colitis-associated cancer (CAC) and the long duration between UC initiation and overt carcinoma, elucidating mechanisms of inflammation-associated carcinogenesis in the gut is particularly challenging. Adequate murine models are thus highly desirable. For human CACs a ...
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Most solid tumors are aneuploid, having a chromosome number that is not a multiple of the haploid number, and many frequently mis-segregate whole chromosomes in a phenomenon called chromosomal instability (CIN). CIN positively correlates with poor patient prognosis, indicating that reduced mitotic fidelity contributes to cancer progression by increasing genetic diversity among tumor cells. Here...
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ژورنال
عنوان ژورنال: Heredity
سال: 1977
ISSN: 0018-067X,1365-2540
DOI: 10.1038/hdy.1977.97